Using the chrome.* APIs, when enabled, the extension forces you to use one tab and window (except incognito windows - but I probably shouldn't have told you that) and kills any new tabs/windows that get created instead replacing the current tab with the new URL.
You can check it out at www.tabzolo.co. It's completely open-sourced on GitHub too if anyone wants to extend its functionality.
What do you think of it?
For more on TabZolo:
GitHub - https://github.com/dasmall/TabZolo
My blog post - http://dazm.co/weekend-project-tabzolo-co/
My co-creator's post - http://leonardocorrea.com/posts/2013-07-14-tabzolo-to-the-rescue/
LifeHacker Mention - http://lifehacker.com/tabzolo-keeps-you-focused-on-one-tab-at-a-time-845544805