If you're developing an API server in nodejs it's a huge quality of life improvement over something like nodemon. Instead of sending a SIGTERM to your process and restarting from scratch, dynohot can replace only the modules which have been updated. It's really just so much faster, you have to see it to believe it.
Also if you're using Webpack to run SSR in something like a React it's helpful too. I found Webpack to be pretty messy on the server side. Since this implements essentially the same API as Webpack and Vite the switch is pretty easy.