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Here's how you get their attention and get the ball rolling...
Rule #1: You must start out by making an offer in your initial email.
Rule #2: This offer must be high enough to get their attention and make them at least THINK.
NOTE: Rule #2's amount will depend on how great the domain is.
The two magic price points I have found that work the best (they depend on how valuable the domain is) is either $1,000 or $2,500.
If it's a great domain then $5K-$10K is usually the starting point. These amounts are enough to get anyone's attention. I've bought many $100K+ value domains for $15K-$20K by starting with a $5K or $7K offer.
By starting with at least something that gets their attention they will take you seriously. This is the first step or you have no chance to make a deal.
In most cases for decent 2 words domains, the $1K to $2.5K opener works best.
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^ This is by someone who had a lot of experience buying and selling domain names, talking about the initial e-mail you send to the domain holder. I have a domain name in mind that I'd like to buy; it's a four-letter nonsense word, but easy to pronounce and spell (2 soft consonants, 2 vowels, not nec in that order). My question: is this a "great domain" for which $5k - $10k should be the starting point, or is it more akin to one of those "decent 2 word domains" for which you could start with $1k to $2.5k?