I saw the talk live and have been positively surprised. The results are good but most important the approach is not invasive and leverages the bytecode compiler while managing to use the original GC.
This Reddit has a good discussion:https://www.reddit.com/r/emacs/comments/g9vdd0/bringing_gnu_emacs_to_native_code_at_the_european/
For the curios there is also a docker image: https://hub.docker.com/r/andreacorallo/emacs-nativecomp