SARS-CoV-2 accesses host cells via the enzyme ACE2[1][2]
On March 11 a correspondence[3] in the Lancet claimed that “the increased expression of ACE2 would facilitate infection with COVID-19” and “ACE2 can also be increased by thiazolidinediones and ibuprofen”
While the first claim seems sensical the authors did not provide a reference for the second claim.
I am not an expert in this area and a search if ibuprofen or NSAIDs[4] really increase ACE2 expression revealed just articles like [5] “Ibuprofen could ameliorate the cardiac fibrosis in diabetic rats by reduction of the ACE/AngII/AT1-R axis and enhancement of the ACE2/Ang(1-7)/Mas-R axis …” which does not really answer my question.
[1] https://en.wikipedia.org/wiki/Coronavirus_disease_2019
[2] https://www.cell.com/cell/fulltext/S0092-8674(20)30229-4
[3] https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/
[4] https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
[5] https://www.ncbi.nlm.nih.gov/pubmed/25896805